Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

Identifying functional enhancer elements in metazoan systems is a major challenge. Large-scale validation of enhancers predicted by ENCODE reveal false-positive rates of at least 70%. We used the pregrastrula-patterning network of Drosophila melanogaster to demonstrate that loss in accuracy in held-...

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Detalles Bibliográficos
Autores principales: Arbel, Hamutal, Basu, Sumanta, Fisher, William W., Hammonds, Ann S., Wan, Kenneth H., Park, Soo, Weiszmann, Richard, Booth, Benjamin W., Keranen, Soile V., Henriquez, Clara, Shams Solari, Omid, Bickel, Peter J., Biggin, Mark D., Celniker, Susan E., Brown, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338827/
https://www.ncbi.nlm.nih.gov/pubmed/30598455
http://dx.doi.org/10.1073/pnas.1808833115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338827/
https://www.ncbi.nlm.nih.gov/pubmed/30598455
http://dx.doi.org/10.1073/pnas.1808833115

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