Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression

The 11-subunit eukaryotic replicative helicase CMG (Cdc45, Mcm2-7, GINS) tightly binds Mcm10, an essential replication protein in all eukaryotes. Here we show that Mcm10 has a potent strand-annealing activity both alone and in complex with CMG. CMG-Mcm10 unwinds and then reanneals single strands soo...

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Detalles Bibliográficos
Autores principales: Mayle, Ryan, Langston, Lance, Molloy, Kelly R., Zhang, Dan, Chait, Brian T., O’Donnell, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338834/
https://www.ncbi.nlm.nih.gov/pubmed/30598452
http://dx.doi.org/10.1073/pnas.1819107116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338834/
https://www.ncbi.nlm.nih.gov/pubmed/30598452
http://dx.doi.org/10.1073/pnas.1819107116

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