Cargando…
Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression
The 11-subunit eukaryotic replicative helicase CMG (Cdc45, Mcm2-7, GINS) tightly binds Mcm10, an essential replication protein in all eukaryotes. Here we show that Mcm10 has a potent strand-annealing activity both alone and in complex with CMG. CMG-Mcm10 unwinds and then reanneals single strands soo...
Autores principales: | Mayle, Ryan, Langston, Lance, Molloy, Kelly R., Zhang, Dan, Chait, Brian T., O’Donnell, Michael E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338834/ https://www.ncbi.nlm.nih.gov/pubmed/30598452 http://dx.doi.org/10.1073/pnas.1819107116 |
Ejemplares similares
-
Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks
por: Langston, Lance D, et al.
Publicado: (2017) -
Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex
por: You, Zhiying, et al.
Publicado: (2017) -
Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase
por: Langston, Lance, et al.
Publicado: (2017) -
Inter-Fork Strand Annealing causes genomic deletions during the termination of DNA replication
por: Morrow, Carl A, et al.
Publicado: (2017) -
The Fml1-MHF complex suppresses inter-fork strand annealing in fission yeast
por: Wong, Io Nam, et al.
Publicado: (2019)