Cargando…
Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters
A major challenge in drug development is the optimization of intestinal absorption and cellular uptake. A successful strategy has been to develop prodrug molecules, which hijack solute carrier (SLC) transporters for active transport into the body. The proton-coupled oligopeptide transporters, PepT1...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338836/ https://www.ncbi.nlm.nih.gov/pubmed/30602453 http://dx.doi.org/10.1073/pnas.1813715116 |