Cargando…
Activation of silent biosynthetic gene clusters using transcription factor decoys
Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases in multiple streptomycetes, and characterization of a novel oxazole family compound produced by...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339570/ https://www.ncbi.nlm.nih.gov/pubmed/30598544 http://dx.doi.org/10.1038/s41589-018-0187-0 |