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Activation of silent biosynthetic gene clusters using transcription factor decoys

Here we report a transcription factor decoy strategy for targeted activation of eight large silent polyketide synthase and non-ribosomal peptide synthetase gene clusters, ranging from 50 to 134 kilobases in multiple streptomycetes, and characterization of a novel oxazole family compound produced by...

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Detalles Bibliográficos
Autores principales: Wang, Bin, Guo, Fang, Dong, Shi-Hui, Zhao, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339570/
https://www.ncbi.nlm.nih.gov/pubmed/30598544
http://dx.doi.org/10.1038/s41589-018-0187-0