A Genetics-Free Method for High-Throughput Discovery of Cryptic Microbial Metabolites

Bacteria harbor an immense, untapped trove of novel secondary metabolites in the form of ‘silent’ biosynthetic gene clusters (BGCs). These can be identified bioinformatically but are not expressed under normal laboratory growth conditions. Methods to access their products would dramatically expand o...

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Detalles Bibliográficos
Autores principales: Xu, Fei, Wu, Yihan, Zhang, Chen, Davis, Katherine M., Moon, Kyuho, Bushin, Leah B., Seyedsayamdost, Mohammad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339573/
https://www.ncbi.nlm.nih.gov/pubmed/30617293
http://dx.doi.org/10.1038/s41589-018-0193-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339573/
https://www.ncbi.nlm.nih.gov/pubmed/30617293
http://dx.doi.org/10.1038/s41589-018-0193-2

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