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A Genetics-Free Method for High-Throughput Discovery of Cryptic Microbial Metabolites
Bacteria harbor an immense, untapped trove of novel secondary metabolites in the form of ‘silent’ biosynthetic gene clusters (BGCs). These can be identified bioinformatically but are not expressed under normal laboratory growth conditions. Methods to access their products would dramatically expand o...
Autores principales: | Xu, Fei, Wu, Yihan, Zhang, Chen, Davis, Katherine M., Moon, Kyuho, Bushin, Leah B., Seyedsayamdost, Mohammad R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339573/ https://www.ncbi.nlm.nih.gov/pubmed/30617293 http://dx.doi.org/10.1038/s41589-018-0193-2 |
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