Rapamycin-mediated mTOR inhibition impairs silencing of sex chromosomes and the pachytene piRNA pathway in the mouse testis

Mechanistic target of rapamycin (mTOR) controls cell growth and metabolism in response to environmental and metabolic signals. Rapamycin robustly extends the lifespan in mammals and has clinical relevance in organ transplantation and cancer therapy but side effects include male infertility. Here, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Zhiping, Yue, Qiuling, Xie, Jie, Zhang, Shuya, He, Wenxiu, Bai, Shun, Tian, Suwen, Zhang, Yingwen, Xiong, Mengneng, Sun, Zheng, Huang, Chaoyang, Li, Yuebei, Zheng, Ke, Ye, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339782/
https://www.ncbi.nlm.nih.gov/pubmed/30636722
http://dx.doi.org/10.18632/aging.101740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339782/
https://www.ncbi.nlm.nih.gov/pubmed/30636722
http://dx.doi.org/10.18632/aging.101740

Ejemplares similares