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Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA
Downregulation of Rpd3 (histone deacetylase) or Loco (regulator of G-protein signaling protein) extends Drosophila lifespan with higher stress resistance. We found rpd3-downregulated long-lived flies genetically interact with loco-upregulated short-lived flies in stress resistance and lifespan. Gene...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Impact Journals
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339784/ https://www.ncbi.nlm.nih.gov/pubmed/30620723 http://dx.doi.org/10.18632/aging.101744 |