CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation. We found that antigen recognition and engagement of the TCR res...

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Detalles Bibliográficos
Autores principales: Laufer, Julia M., Kindinger, Ilona, Artinger, Marc, Pauli, Andreas, Legler, Daniel F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339918/
https://www.ncbi.nlm.nih.gov/pubmed/30692994
http://dx.doi.org/10.3389/fimmu.2018.03115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339918/
https://www.ncbi.nlm.nih.gov/pubmed/30692994
http://dx.doi.org/10.3389/fimmu.2018.03115

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