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Inhibitory Receptor Crosslinking Quantitatively Dampens Calcium Flux Induced by Activating Receptor Triggering in NK Cells

Natural killer (NK) cell function is regulated by a balance between activating and inhibitory receptors, but the details of this receptor interplay are not extensively understood. We developed a flow cytometry-based assay system in which Ca(2+) flux downstream of antibody-mediated activating recepto...

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Detalles Bibliográficos
Autores principales: Ganesan, Sridharan, Höglund, Petter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339929/
https://www.ncbi.nlm.nih.gov/pubmed/30693005
http://dx.doi.org/10.3389/fimmu.2018.03173