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Ca(2+)-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains

The Ca(2+) sensor calmodulin (CaM) regulates cardiac ryanodine receptor (RyR2)-mediated Ca(2+) release from the sarcoplasmic reticulum. CaM inhibits RyR2 in a Ca(2+)-dependent manner and aberrant CaM-dependent inhibition results in life-threatening cardiac arrhythmias. However, the molecular details...

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Detalles Bibliográficos
Autores principales:	Brohus, Malene, Søndergaard, Mads T., Wayne Chen, Sui Rong, vanPetegem, Filip, Overgaard, Michael T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340113/ https://www.ncbi.nlm.nih.gov/pubmed/30530841 http://dx.doi.org/10.1042/BCJ20180545

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