Cargando…
Inducible IFN-γ Expression for MHC-I Upregulation in Devil Facial Tumor Cells
The Tasmanian devil facial tumor (DFT) disease has led to an 80% reduction in the wild Tasmanian devil (Sarcophilus harrisii) population since 1996. The limited genetic diversity of wild devils and the lack of MHC-I expression on DFT cells have been implicated in the lack of immunity against the ori...
Autores principales: | Ong, Chrissie E. B., Lyons, Alan Bruce, Woods, Gregory M., Flies, Andrew S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340284/ https://www.ncbi.nlm.nih.gov/pubmed/30692995 http://dx.doi.org/10.3389/fimmu.2018.03117 |
Ejemplares similares
-
Class II transactivator induces expression of MHC-I and MHC-II in transmissible Tasmanian devil facial tumours
por: Ong, Chrissie E. B., et al.
Publicado: (2022) -
PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor Cells but Is Strongly Upregulated in Response to IFN-γ and Can Be Expressed in the Tumor Microenvironment
por: Flies, Andrew S., et al.
Publicado: (2016) -
Comparative Analysis of Immune Checkpoint Molecules and Their Potential Role in the Transmissible Tasmanian Devil Facial Tumor Disease
por: Flies, Andrew S., et al.
Publicado: (2017) -
NLRC5 regulates expression of MHC-I and provides a target for anti-tumor immunity in transmissible cancers
por: Ong, Chrissie E. B., et al.
Publicado: (2021) -
Immunization Strategies Producing a Humoral IgG Immune Response against Devil Facial Tumor Disease in the Majority of Tasmanian Devils Destined for Wild Release
por: Pye, Ruth, et al.
Publicado: (2018)