RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood. Here, we reconstitute accelerated and selective deadenylation of...

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Detalles Bibliográficos
Autores principales: Webster, Michael W, Stowell, James AW, Passmore, Lori A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340701/
https://www.ncbi.nlm.nih.gov/pubmed/30601114
http://dx.doi.org/10.7554/eLife.40670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340701/
https://www.ncbi.nlm.nih.gov/pubmed/30601114
http://dx.doi.org/10.7554/eLife.40670

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