The N(6)-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy

BACKGROUND: N(6)-Methyladenosine (m6A) methylation is the most prevalent internal posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation in the heart is not known. METHODS: To determine the role of m6A methylation in the heart, we isolated primary cardiomyocytes and per...

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Detalles Bibliográficos
Autores principales: Dorn, Lisa E., Lasman, Lior, Chen, Jing, Xu, Xianyao, Hund, Thomas J., Medvedovic, Mario, Hanna, Jacob H., van Berlo, Jop H., Accornero, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340720/
https://www.ncbi.nlm.nih.gov/pubmed/30586742
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340720/
https://www.ncbi.nlm.nih.gov/pubmed/30586742
http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036146

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