Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity

This work tests bioenergetic and cell-biological implications of the synthetic fatty acid Minerval (2-hydroxyoleic acid), previously demonstrated to act by activation of sphingomyelin synthase in the plasma membrane (PM) and lowering of phosphatidylethanolamine (PE) and phosphatidylcholine (PC) and...

Descripción completa

Detalles Bibliográficos
Autores principales: Massalha, Wessal, Markovits, Mark, Pichinuk, Edward, Feinstein-Rotkopf, Yael, Tarshish, Mark, Mishra, Kumudesh, Llado, Victoria, Weil, Miguel, Escriba, Pablo V., Kakhlon, Or
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340956/
https://www.ncbi.nlm.nih.gov/pubmed/30602451
http://dx.doi.org/10.1042/BSR20181661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340956/
https://www.ncbi.nlm.nih.gov/pubmed/30602451
http://dx.doi.org/10.1042/BSR20181661

Ejemplares similares