Constitutional mislocalization of Pten drives precocious maturation in oligodendrocytes and aberrant myelination in model of autism spectrum disorder

There is a strong genetic association between germline PTEN mutation and autism spectrum disorder (ASD), making Pten-mutant models exemplary for the study of ASD pathophysiology. We developed the Pten(m3m4) mouse, where Pten is largely restricted from the nucleus, which recapitulates patient-like, a...

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Detalles Bibliográficos
Autores principales: Lee, Hyunpil, Thacker, Stetson, Sarn, Nicholas, Dutta, Ranjan, Eng, Charis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341090/
https://www.ncbi.nlm.nih.gov/pubmed/30664625
http://dx.doi.org/10.1038/s41398-018-0364-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341090/
https://www.ncbi.nlm.nih.gov/pubmed/30664625
http://dx.doi.org/10.1038/s41398-018-0364-7

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