BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

In Drosophila, a complex consisting of Calypso and ASX catalyzes H2A deubiquitination and has been reported to act as part of the Polycomb machinery in transcriptional silencing. The mammalian homologs of these proteins (BAP1 and ASXL1/2/3, respectively), are frequently mutated in various cancer typ...

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Detalles Bibliográficos
Autores principales: Campagne, Antoine, Lee, Ming-Kang, Zielinski, Dina, Michaud, Audrey, Le Corre, Stéphanie, Dingli, Florent, Chen, Hong, Shahidian, Lara Z., Vassilev, Ivaylo, Servant, Nicolas, Loew, Damarys, Pasmant, Eric, Postel-Vinay, Sophie, Wassef, Michel, Margueron, Raphaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341105/
https://www.ncbi.nlm.nih.gov/pubmed/30664650
http://dx.doi.org/10.1038/s41467-018-08255-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341105/
https://www.ncbi.nlm.nih.gov/pubmed/30664650
http://dx.doi.org/10.1038/s41467-018-08255-x

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