Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Wnt-induced β-catenin-mediated transcription is a driving force for stem cell self-renewal during adult tissue homeostasis. Enhanced Wnt receptor expression due to mutational inactivation of the ubiquitin ligases RNF43/ZNRF3 recently emerged as a leading cause for cancer development. Consequently, t...

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Detalles Bibliográficos
Autores principales: Fenderico, Nicola, van Scherpenzeel, Revina C., Goldflam, Michael, Proverbio, Davide, Jordens, Ingrid, Kralj, Tomica, Stryeck, Sarah, Bass, Tarek Z., Hermans, Guy, Ullman, Christopher, Aastrup, Teodor, Gros, Piet, Maurice, Madelon M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341108/
https://www.ncbi.nlm.nih.gov/pubmed/30664649
http://dx.doi.org/10.1038/s41467-018-08172-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341108/
https://www.ncbi.nlm.nih.gov/pubmed/30664649
http://dx.doi.org/10.1038/s41467-018-08172-z

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