Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine. Here we show that VSPs not only are resistant to proteolytic digestion and extreme pH and temperature...

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Detalles Bibliográficos
Autores principales: Serradell, Marianela C., Rupil, Lucía L., Martino, Román A., Prucca, César G., Carranza, Pedro G., Saura, Alicia, Fernández, Elmer A., Gargantini, Pablo R., Tenaglia, Albano H., Petiti, Juan P., Tonelli, Renata R., Reinoso-Vizcaino, Nicolás, Echenique, José, Berod, Luciana, Piaggio, Eliane, Bellier, Bertrand, Sparwasser, Tim, Klatzmann, David, Luján, Hugo D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341118/
https://www.ncbi.nlm.nih.gov/pubmed/30664644
http://dx.doi.org/10.1038/s41467-018-08265-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341118/
https://www.ncbi.nlm.nih.gov/pubmed/30664644
http://dx.doi.org/10.1038/s41467-018-08265-9

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