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Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins
Intestinal and free-living protozoa, such as Giardia lamblia, express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host’s intestine. Here we show that VSPs not only are resistant to proteolytic digestion and extreme pH and temperature...
Autores principales: | Serradell, Marianela C., Rupil, Lucía L., Martino, Román A., Prucca, César G., Carranza, Pedro G., Saura, Alicia, Fernández, Elmer A., Gargantini, Pablo R., Tenaglia, Albano H., Petiti, Juan P., Tonelli, Renata R., Reinoso-Vizcaino, Nicolás, Echenique, José, Berod, Luciana, Piaggio, Eliane, Bellier, Bertrand, Sparwasser, Tim, Klatzmann, David, Luján, Hugo D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341118/ https://www.ncbi.nlm.nih.gov/pubmed/30664644 http://dx.doi.org/10.1038/s41467-018-08265-9 |
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