High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17(+)IL-10(+) Memory CD4(+) T Cell Response towards a Single IL-10–Producing Phenotype

Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics. However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in excess, is associated with increased asthma severity a...

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Detalles Bibliográficos
Autores principales: Mann, Elizabeth H., Gabryšová, Leona, Pfeffer, Paul E., O’Garra, Anne, Hawrylowicz, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AAI 2019
Materias:
Clinical and Human Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341182/
https://www.ncbi.nlm.nih.gov/pubmed/30598515
http://dx.doi.org/10.4049/jimmunol.1800697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341182/
https://www.ncbi.nlm.nih.gov/pubmed/30598515
http://dx.doi.org/10.4049/jimmunol.1800697

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