Cargando…

Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes

OBJECTIVE: Abnormally elevated proinsulin secretion has been reported in type 2 and early type 1 diabetes when significant C-peptide is present. We questioned whether individuals with long-standing type 1 diabetes and low or absent C-peptide secretory capacity retained the ability to make proinsulin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sims, Emily K., Bahnson, Henry T., Nyalwidhe, Julius, Haataja, Leena, Davis, Asa K., Speake, Cate, DiMeglio, Linda A., Blum, Janice, Morris, Margaret A., Mirmira, Raghavendra G., Nadler, Jerry, Mastracci, Teresa L., Marcovina, Santica, Qian, Wei-Jun, Yi, Lian, Swensen, Adam C., Yip-Schneider, Michele, Schmidt, C. Max, Considine, Robert V., Arvan, Peter, Greenbaum, Carla J., Evans-Molina, Carmella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2019
Materias:	Pathophysiology/Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341288/ https://www.ncbi.nlm.nih.gov/pubmed/30530850 http://dx.doi.org/10.2337/dc17-2625

Ejemplares similares

Response to Comment on Sims et al. Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes. Diabetes Care 2019;42:258–264
por: Sims, Emily K., et al.
Publicado: (2019)

Prevalence of and Risk Factors for Diabetic Peripheral Neuropathy in Youth With Type 1 and Type 2 Diabetes: SEARCH for Diabetes in Youth Study
por: Jaiswal, Mamta, et al.
Publicado: (2017)

Comparison of β-Cell Function Between Overweight/Obese Adults and Adolescents Across the Spectrum of Glycemia
por: Chen, Melinda E., et al.
Publicado: (2018)

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes
por: Cousminer, Diana L., et al.
Publicado: (2018)

Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset
por: Rodriguez-Calvo, Teresa, et al.
Publicado: (2017)

Risk Factors Related to Inflammation and Endothelial Dysfunction in the DCCT/EDIC Cohort and Their Relationship With Nephropathy and Macrovascular Complications
por: Lopes-Virella, Maria F., et al.
Publicado: (2008)

Testosterone Concentration in Young Patients With Diabetes
por: Chandel, Anil, et al.
Publicado: (2008)

Serum Xylosyltransferase Activity in Diabetic Patients as a Possible Marker of Reduced Proteoglycan Biosynthesis
por: Götting, Christian, et al.
Publicado: (2008)

Glucose and C-Peptide Changes in the Perionset Period of Type 1 Diabetes in the Diabetes Prevention Trial–Type 1
por: Sosenko, Jay M., et al.
Publicado: (2008)

Pregnancy Insulin, Glucose, and BMI Contribute to Birth Outcomes in Nondiabetic Mothers
por: Ong, Ken K., et al.
Publicado: (2008)

A1C Variability and the Risk of Microvascular Complications in Type 1 Diabetes: Data from the Diabetes Control and Complications Trial
por: Kilpatrick, Eric S., et al.
Publicado: (2008)

Euglycemic Hyperinsulinemia Alters the Response to Orthostatic Stress in Older Adults With Type 2 Diabetes
por: Madden, Kenneth M., et al.
Publicado: (2008)

Insulin Administration and Rate of Glucose Appearance in People With Type 1 Diabetes
por: Pennant, Mary E., et al.
Publicado: (2008)

Adipose Tissue Lipolysis Is Upregulated in Lean and Obese Men During Acute Resistance Exercise
por: Chatzinikolaou, Athanasios, et al.
Publicado: (2008)

Trends in High-Risk HLA Susceptibility Genes Among Colorado Youth With Type 1 Diabetes
por: Vehik, Kendra, et al.
Publicado: (2008)

Too Much Glucagon, Too Little Insulin: Time course of pancreatic islet dysfunction in new-onset type 1 diabetes
por: Brown, Rebecca J., et al.
Publicado: (2008)

Increased Shear Rate Resistance and Fastest Kinetics of Erythrocyte Aggregation in Diabetes Measured With Ultrasound
por: Cloutier, Guy, et al.
Publicado: (2008)

Acute Modulation of Toll-Like Receptors by Insulin
por: Ghanim, Husam, et al.
Publicado: (2008)

Progression of Cardiovascular Autonomic Dysfunction in Patients With Type 2 Diabetes: A 7-year follow-up study
por: Ko, Seung-Hyun, et al.
Publicado: (2008)

Prevalence and Risk Factors for Neuropathy in a Canadian First Nation Community
por: Bruce, Sharon G., et al.
Publicado: (2008)

Retinal Arteriolar Dilation Predicts Retinopathy in Adolescents With Type 1 Diabetes
por: Cheung, Ning, et al.
Publicado: (2008)

Prognostic Value of the Insertion/Deletion Polymorphism of the ACE Gene in Type 2 Diabetic Subjects: Results from the Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril (DIABHYCAR), Diabete de type 2, Nephropathie et Genetique (DIAB2NEPHROGENE), and Survie, Diabete de type 2 et Genetique (SURDIAGENE) studies
por: Hadjadj, Samy, et al.
Publicado: (2008)

Associations of Renal Vascular Resistance With Albuminuria and Other Macroangiopathy in Type 2 Diabetic Patients
por: Hamano, Kumiko, et al.
Publicado: (2008)

Maternal Lipids as Strong Determinants of Fetal Environment and Growth in Pregnancies With Gestational Diabetes Mellitus
por: Schaefer-Graf, Ute M., et al.
Publicado: (2008)

Oxidation, Type 2 Diabetes, and Coronary Heart Disease: A Complex Interaction: Findings from a population-based study
por: Stranges, Saverio, et al.
Publicado: (2008)

Short-Term Hyperglycemic Dysregulation in Patients With Type 1 Diabetes Does Not Change Myocardial Triglyceride Content or Myocardial Function
por: Hammer, Sebastiaan, et al.
Publicado: (2008)

Epidermal Innervation in Type 1 Diabetic Patients: A 2.5-year prospective study after simultaneous pancreas/kidney transplantation
por: Boucek, Petr, et al.
Publicado: (2008)

GAD65 Autoantibody Responses in Japanese Latent Autoimmune Diabetes in Adult Patients
por: Maruyama, Taro, et al.
Publicado: (2008)

Association Between p.Leu54Met Polymorphism at the Paraoxonase-1 Gene and Plantar Fascia Thickness in Young Subjects With Type 1 Diabetes
por: Gallego, Patricia H., et al.
Publicado: (2008)

Diminished Alveolar Microvascular Reserves in Type 2 Diabetes Reflect Systemic Microangiopathy
por: Chance, William W., et al.
Publicado: (2008)

Hyperglycemia Is Associated With Enhanced Thrombin Formation, Platelet Activation, and Fibrin Clot Resistance to Lysis in Patients With Acute Coronary Syndrome
por: Undas, Anetta, et al.
Publicado: (2008)

Differences in the Contribution of the CTLA4 Gene to Susceptibility to Fulminant and Type 1A Diabetes in Japanese Patients
por: Kawasaki, Eiji, et al.
Publicado: (2008)

Weight Gain in Early Life Predicts Risk of Islet Autoimmunity in Children With a First-Degree Relative With Type 1 Diabetes
por: Couper, Jennifer J., et al.
Publicado: (2009)

In Vivo Insulin Sensitivity and Secretion in Obese Youth: What are the differences between normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes?
por: Bacha, Fida, et al.
Publicado: (2009)

Quantitative Assessment of Early Diabetic Retinopathy Using Fractal Analysis
por: Cheung, Ning, et al.
Publicado: (2009)

Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes
por: Rubio-Cabezas, Oscar, et al.
Publicado: (2009)

Increased Matrix Metalloproteinase-9 Predicts Poor Wound Healing in Diabetic Foot Ulcers
por: Liu, Yu, et al.
Publicado: (2009)

Gestational Diabetes Mellitus Upsets the Proportion of Fatty Acids in Umbilical Arterial but Not Venous Plasma
por: Ortega-Senovilla, Henar, et al.
Publicado: (2009)

Insulin Gene Mutations as Cause of Diabetes in Children Negative for Five Type 1 Diabetes Autoantibodies
por: Bonfanti, Riccardo, et al.
Publicado: (2009)

Serum Levels of the Adipokine FGF21 Depend on Renal Function
por: Stein, Sebastian, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_0v7v84pb6q8a479n4l7phe2cml