Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons

BACKGROUND: Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes to human NTDs. We examined the potential role of hypermethylation of Pax3 i...

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Detalles Bibliográficos
Autores principales: Lin, Shanshan, Ren, Aiguo, Wang, Linlin, Santos, Chloe, Huang, Yun, Jin, Lei, Li, Zhiwen, Greene, Nicholas D. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341549/
https://www.ncbi.nlm.nih.gov/pubmed/30665459
http://dx.doi.org/10.1186/s13148-019-0611-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341549/
https://www.ncbi.nlm.nih.gov/pubmed/30665459
http://dx.doi.org/10.1186/s13148-019-0611-7

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