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NEP(1-40)-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury
BACKGROUND: Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which can enca...
Autores principales: | Lin, Yan, Li, Chunhong, Li, Jian, Deng, Ruolan, Huang, Juan, Zhang, Qinglian, Lyu, Jiayao, Hao, Na, Zhong, Zhirong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341626/ https://www.ncbi.nlm.nih.gov/pubmed/30670038 http://dx.doi.org/10.1186/s12951-019-0449-3 |
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