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Prediction of functional microRNA targets by integrative modeling of microRNA binding and target expression data

We perform a large-scale RNA sequencing study to experimentally identify genes that are downregulated by 25 miRNAs. This RNA-seq dataset is combined with public miRNA target binding data to systematically identify miRNA targeting features that are characteristic of both miRNA binding and target down...

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Detalles Bibliográficos
Autores principales: Liu, Weijun, Wang, Xiaowei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341724/
https://www.ncbi.nlm.nih.gov/pubmed/30670076
http://dx.doi.org/10.1186/s13059-019-1629-z