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The tumor suppressor OVCA1 is a short half-life protein degraded by the ubiquitin-proteasome pathway

Ovarian cancer gene 1 (OVCA1) is a tumor suppressor associated with ovarian cancer, which is involved in cell proliferation regulation, embryonic development and tumorigenesis. Loss of heterozygosity in the OVCA1 gene occurs in 50–86% of cases of ovarian cancer; however, the physiological and bioche...

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Detalles Bibliográficos
Autores principales: Lin, Yingwei, Kong, Fandou, Li, Yan, Wang, Yinghui, Song, Ling, Zhao, Chunyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341780/
https://www.ncbi.nlm.nih.gov/pubmed/30675298
http://dx.doi.org/10.3892/ol.2018.9852