Cargando…

Electrocardiographic Effects of a Supratherapeutic Dose of WCK 2349, a Benzoquinolizine Fluoroquinolone

The purpose of this study was to measure the electrocardiographic (ECG) effects of WCK 2349 (the L‐alanine ester prodrug of levonadifloxacin) at a supratherapeutic oral dose of 2,600 mg. A total of 48 healthy volunteers were randomized to treatment with placebo, WCK 2349, or oral moxifloxacin, 400 m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mason, Jay W., Chugh, Rakesh, Patel, Anasuya, Gutte, Ranjeet, Bhatia, Ashima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342240/ https://www.ncbi.nlm.nih.gov/pubmed/30369076 http://dx.doi.org/10.1111/cts.12594

Ejemplares similares

In Vitro activity of a Novel Benzoquinolizine Antibiotic, Levonadifloxacin (WCK 771) against Blood Stream Gram-Positive Isolates from a Tertiary Care Hospital
por: Mamtora, Dhruv, et al.
Publicado: (2020)

Levonadifloxacin, a Novel Broad-Spectrum Anti-MRSA Benzoquinolizine Quinolone Agent: Review of Current Evidence
por: Bhagwat, Sachin S, et al.
Publicado: (2019)

HPLC Method for Determination of Enantiomeric Purity of a Novel Respiratory Fluoroquinolone: WCK 1152
por: Yeole, R. D., et al.
Publicado: (2008)

An evaluation of a supratherapeutic dose of inclisiran on cardiac repolarization in healthy volunteers: A phase I, randomized study
por: Kallend, David, et al.
Publicado: (2022)

Efficient Synthesis of Potential Impurities in Levonadifloxacin (WCK 771)
por: Kilbile, Jaydeo T., et al.
Publicado: (2021)

2349 The role of interleukin-23 in human melanoma
por: Jani, Aditi, et al.
Publicado: (2018)

Activity of ertapenem/zidebactam (WCK 6777) against problem Enterobacterales
por: Mushtaq, Shazad, et al.
Publicado: (2022)

A Retrospective Review of Supratherapeutic Modafinil Exposures
por: Carstairs, Shaun D., et al.
Publicado: (2010)

Spontaneous Epiglottic Hematoma Secondary to Supratherapeutic Anticoagulation
por: Koch, Cody A., et al.
Publicado: (2010)

A single supratherapeutic dose of ridaforolimus does not prolong the QTc interval in patients with advanced cancer
por: Lush, Richard M., et al.
Publicado: (2012)

Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study
por: Shen, Zancong, et al.
Publicado: (2016)

Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals
por: Darpo, Borje, et al.
Publicado: (2017)

Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization
por: Langenickel, Thomas H., et al.
Publicado: (2016)

Supratherapeutic anti-factor Xa levels in patients receiving prophylactic doses of enoxaparin: A case series
por: Pannucci, Christopher J., et al.
Publicado: (2016)

A CONTROVERSY: WARFARIN FAILURE IN COVID-19 WITH SUPRATHERAPEUTIC INR
por: Ur Rahman, Saad
Publicado: (2023)

A Case of Symptomatic Supratherapeutic International Normalized Ratio on Rivaroxaban
por: Khidhir, Angela, et al.
Publicado: (2023)

A Prospective Multicenter Study to Evaluate the Safety and Efficacy of the Topical Application of MYOWNN™, an Autologous Growth Factor Concentrate (AGFC) Serum, in Anti-Aging
por: Chandrashekar, B. S., et al.
Publicado: (2022)

2,3,4,9-Tetrahydro-1H-carbazole
por: Murugavel, S., et al.
Publicado: (2008)

Extensive Upper Airway Hematoma Secondary to Supratherapeutic Warfarin Anticoagulation
por: Oyedokun, Taofiq Olusegun, et al.
Publicado: (2020)

No effect of a single supratherapeutic dose of lersivirine, a next-generation NNRTI, on QTc interval in healthy subjects
por: Vourvahis, M, et al.
Publicado: (2010)

A Thorough QT Study to Evaluate the Effects of a Supratherapeutic Dose of Sertraline on Cardiac Repolarization in Healthy Subjects
por: Abbas, Richat, et al.
Publicado: (2019)

Lenalidomide at Therapeutic and Supratherapeutic Doses Does Not Prolong QTc Intervals in the Thorough QTc Study Conducted in Healthy Men
por: Chen, Nianhang, et al.
Publicado: (2013)

Effect of Therapeutic and Supratherapeutic Doses of Vonoprazan on the QT/QTc Interval in a Phase I Randomized Study in Healthy Subjects
por: Astruc, B, et al.
Publicado: (2017)

Single Therapeutic and Supratherapeutic Doses of Ubrogepant Do Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized Trial
por: Jakate, Abhijeet, et al.
Publicado: (2019)

Supratherapeutic anticoagulation at presentation is associated with reduced mortality in nonvariceal upper gastrointestinal hemorrhage
por: Irwin, James, et al.
Publicado: (2014)

2349: Development of a Pediatric Hydrocephalus Severity Index to predict long-term clinical outcomes
por: Han, Rowland, et al.
Publicado: (2018)

Supratherapeutic International Normalized Ratio causing Nephropathy: A Rare Adverse Effect of Warfarin
por: Rawala, Muhammad Shabbir, et al.
Publicado: (2019)

Cefepime-Zidebactam (WCK 5222) Activity Tested against Gram-negative Organisms Causing Bloodstream Infections Worldwide
por: Sader, Helio S, et al.
Publicado: (2017)

Delayed intrinsicoid deflection: Electrocardiographic harbinger of heart disease
por: Aiken, Achilles V., et al.
Publicado: (2022)

Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QT(c) interval in healthy subjects
por: Darpö, Börje, et al.
Publicado: (2013)

Porphyria cutanea tarda unmasked by supratherapeutic estrogen during gender-affirming hormone therapy
por: Jackson Cullison, Stephanie R., et al.
Publicado: (2020)

Dolutegravir in pregnant mice is associated with increased rates of fetal defects at therapeutic but not at supratherapeutic levels
por: Mohan, Haneesha, et al.
Publicado: (2020)

SAT391 Supratherapeutic Estrogen Levels in Transgender Women Likely From Sublingual Estradiol
por: Jalal, Erica, et al.
Publicado: (2023)

Role of H- and D- MATE-Type Transporters from Multidrug Resistant Clinical Isolates of Vibrio fluvialis in Conferring Fluoroquinolone Resistance
por: Mohanty, Priyabrata, et al.
Publicado: (2012)

A Single Supratherapeutic Dose of Atogepant Does Not Affect Cardiac Repolarization in Healthy Adults: Results From a Randomized, Single‐Dose, Phase 1 Crossover Trial
por: Boinpally, Ramesh, et al.
Publicado: (2021)

PB2349: A PHASE 1, OPEN-LABEL, MULTICENTER, DOSE-ESCALATION STUDY OF SGR-1505 AS MONOTHERAPY IN SUBJECTS WITH MATURE B-CELL MALIGNANCIES
por: Olszewski, Adam, et al.
Publicado: (2023)

In vivo efficacy of WCK 6777 (ertapenem/zidebactam) against carbapenemase-producing Klebsiella pneumoniae in the neutropenic murine pneumonia model
por: Gethers, Matthew, et al.
Publicado: (2022)

6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-thione
por: Archana, R., et al.
Publicado: (2011)

8-Methyl-2,3,4,9-tetrahydro-1H-carbazol-1-one
por: Archana, R., et al.
Publicado: (2010)

PReS-FINAL-2349: Spectrum of thrombotic and non-thrombotic manifestations in 159 children with positive antiphospholipid antibodies
por: Rozic, M, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_o2r15ivee8b9mmsl0ld7vad6gf