Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator

Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at target promoters for gene silencing. Here, we report that EZH2 activates androgen receptor (AR) gene transcription through direct occupancy a...

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Detalles Bibliográficos
Autores principales: Kim, Jung, Lee, Yongik, Lu, Xiaodong, Song, Bing, Fong, Ka-Wing, Cao, Qi, Licht, Jonathan D., Zhao, Jonathan C., Yu, Jindan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342284/
https://www.ncbi.nlm.nih.gov/pubmed/30517868
http://dx.doi.org/10.1016/j.celrep.2018.11.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342284/
https://www.ncbi.nlm.nih.gov/pubmed/30517868
http://dx.doi.org/10.1016/j.celrep.2018.11.035

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