Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is cleaved but subsequently relegated forming a stable...

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Detalles Bibliográficos
Autores principales: Chen, Xingchen, Riley, Blake T., de Veer, Simon J., Hoke, David E., Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E., Brattsand, Maria, Hartfield, Perry J., Buckle, Ashley M., Harris, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342301/
https://www.ncbi.nlm.nih.gov/pubmed/30668585
http://dx.doi.org/10.1371/journal.pone.0210842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342301/
https://www.ncbi.nlm.nih.gov/pubmed/30668585
http://dx.doi.org/10.1371/journal.pone.0210842

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