Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting

Extensive cell-to-cell variation exists even among putatively identical cells, and there is great interest in understanding how the properties of transcription relate to this heterogeneity. Differential expression from the two gene copies in diploid cells could potentially contribute, yet our abilit...

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Detalles Bibliográficos
Autores principales: Symmons, Orsolya, Chang, Marcello, Mellis, Ian A., Kalish, Jennifer M., Park, Jihwan, Suszták, Katalin, Bartolomei, Marisa S., Raj, Arjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342324/
https://www.ncbi.nlm.nih.gov/pubmed/30625149
http://dx.doi.org/10.1371/journal.pgen.1007874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342324/
https://www.ncbi.nlm.nih.gov/pubmed/30625149
http://dx.doi.org/10.1371/journal.pgen.1007874

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