Cargando…

The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: a two-step, two-sample Mendelian randomisation study

AIMS/HYPOTHESIS: The extent to which effects of BMI on CHD are mediated by glycaemic and lipid risk factors is unclear. In this study we examined the effects of these traits using genetic evidence. METHODS: We used two-sample Mendelian randomisation to determine: (1) the causal effect of BMI on CHD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Lin, Borges, Maria Carolina, Hemani, Gibran, Lawlor, Debbie A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342872/ https://www.ncbi.nlm.nih.gov/pubmed/28889241 http://dx.doi.org/10.1007/s00125-017-4396-y

Ejemplares similares

Commentary: Two-sample Mendelian randomization: opportunities and challenges
por: Lawlor, Debbie A
Publicado: (2016)

Two-sample Mendelian randomization: avoiding the downsides of a powerful, widely applicable but potentially fallible technique
por: Hartwig, Fernando Pires, et al.
Publicado: (2016)

Lung function, COPD and cognitive function: a multivariable and two sample Mendelian randomization study
por: Higbee, Daniel H., et al.
Publicado: (2021)

The effect of maternal BMI, smoking and alcohol on congenital heart diseases: a Mendelian randomisation study
por: Taylor, Kurt, et al.
Publicado: (2023)

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations
por: Hartwig, Fernando Pires, et al.
Publicado: (2021)

Role of Adiponectin in Coronary Heart Disease Risk: A Mendelian Randomization Study
por: Borges, Maria Carolina, et al.
Publicado: (2016)

Recent Developments in Mendelian Randomization Studies
por: Zheng, Jie, et al.
Publicado: (2017)

Design and quality control of large-scale two-sample Mendelian randomization studies
por: Haycock, Philip C, et al.
Publicado: (2023)

Genetic Association and Potential Mediators between Sarcopenia and Coronary Heart Disease: A Bidirectional Two-Sample, Two-Step Mendelian Randomization Study
por: He, Junyi, et al.
Publicado: (2023)

Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies using the MR-Base platform
por: Woolf, Benjamin, et al.
Publicado: (2022)

Mendelian randomization: genetic anchors for causal inference in epidemiological studies
por: Davey Smith, George, et al.
Publicado: (2014)

Two-Sample Mendelian Randomization Study of Lipid levels and Ischemic Heart Disease
por: Lee, Su Hyun, et al.
Publicado: (2020)

Education, intelligence and Alzheimer’s disease: evidence from a multivariable two-sample Mendelian randomization study
por: Anderson, Emma L, et al.
Publicado: (2020)

Evaluating the potential role of pleiotropy in Mendelian randomization studies
por: Hemani, Gibran, et al.
Publicado: (2018)

Evaluating and implementing block jackknife resampling Mendelian randomization to mitigate bias induced by overlapping samples
por: Fang, Si, et al.
Publicado: (2022)

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts
por: Palmer, Tom M, et al.
Publicado: (2013)

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
por: White, Jon, et al.
Publicado: (2016)

Elucidating the role of maternal environmental exposures on offspring health and disease using two-sample Mendelian randomization
por: Evans, David M, et al.
Publicado: (2019)

Mendelian Randomisation Study of Childhood BMI and Early Menarche
por: Mumby, Hannah S., et al.
Publicado: (2011)

Improving the accuracy of two-sample summary-data Mendelian randomization: moving beyond the NOME assumption
por: Bowden, Jack, et al.
Publicado: (2019)

Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants
por: Borges, Maria Carolina, et al.
Publicado: (2022)

Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation
por: Wang, Zhiyang, et al.
Publicado: (2023)

The Effect of BMI and Type 2 Diabetes on Socioeconomic Status: A Two-Sample Multivariable Mendelian Randomization Study
por: Pedron, Sara, et al.
Publicado: (2021)

Exploring the Lifetime Effect of Children on Wellbeing Using Two-Sample Mendelian Randomisation
por: Woolf, Benjamin, et al.
Publicado: (2023)

Mendelian randomization of blood lipids for coronary heart disease
por: Holmes, Michael V., et al.
Publicado: (2015)

Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study
por: Noyce, Alastair J., et al.
Publicado: (2017)

Rheumatoid arthritis and coronary atherosclerosis: a two-sample Mendelian randomization study
por: Nie, Qiong, et al.
Publicado: (2023)

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis
por: Anderson, Emma L, et al.
Publicado: (2020)

Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?
por: Bowden, Jack, et al.
Publicado: (2018)

Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study
por: Cui, Yongjia, et al.
Publicado: (2023)

Adipokines and risk of rheumatoid arthritis: A two-sample multivariable Mendelian randomisation study
por: Vasileiadis, Georgios K., et al.
Publicado: (2023)

The use of negative control outcomes in Mendelian randomization to detect potential population stratification
por: Sanderson, Eleanor, et al.
Publicado: (2021)

A two-sample Mendelian randomization study of circulating lipids and deep venous thrombosis
por: Luo, Pan, et al.
Publicado: (2023)

Investigating the association between glycaemic traits and colorectal cancer in the Japanese population using Mendelian randomisation
por: Hanyuda, Akiko, et al.
Publicado: (2023)

Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study
por: Russell, Abigail Emma, et al.
Publicado: (2020)

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight
por: Hwang, Liang-Dar, et al.
Publicado: (2019)

Using Mendelian Randomisation to Prioritise Candidate Maternal Metabolic Traits Influencing Offspring Birthweight
por: Barry, Ciarrah-Jane Shannon, et al.
Publicado: (2022)

Education and coronary heart disease: mendelian randomisation study
por: Tillmann, Taavi, et al.
Publicado: (2017)

Handgrip strength and the risk of major depressive disorder: a two-sample Mendelian randomisation study
por: Li, Nanxi, et al.
Publicado: (2022)

Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
por: Long, Yiwen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_buk7eagcb3r0lv25o9n62i24gp