Correlations between metabolism and structural elements of the alicyclic fentanyl analogs cyclopropyl fentanyl, cyclobutyl fentanyl, cyclopentyl fentanyl, cyclohexyl fentanyl and 2,2,3,3-tetramethylcyclopropyl fentanyl studied by human hepatocytes and LC-QTOF-MS

Recently, a number of fentanyl analogs have been implicated in overdose deaths in Europe and in the US. So far, little is known of the molecular behavior of the structurally related subgroup; the alicyclic fentanyls. In this study, reference standards of cyclopropyl, cyclobutyl, cyclopentyl, cyclohe...

Descripción completa

Detalles Bibliográficos
Autores principales: Åstrand, Anna, Töreskog, Amanda, Watanabe, Shimpei, Kronstrand, Robert, Gréen, Henrik, Vikingsson, Svante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Toxicokinetics and Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342890/
https://www.ncbi.nlm.nih.gov/pubmed/30361799
http://dx.doi.org/10.1007/s00204-018-2330-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342890/
https://www.ncbi.nlm.nih.gov/pubmed/30361799
http://dx.doi.org/10.1007/s00204-018-2330-9

Ejemplares similares