Maintenance of the bladder cancer precursor urothelial hyperplasia requires FOXA1 and persistent expression of oncogenic HRAS

Tumorigenesis requires accumulation of genetic and epigenetic alterations, some of which drive tumor initiation. “Oncogene addiction” describes the phenomenon that (1) well-established cancers are dependent on one mutated oncogene or pathway for the maintenance of a malignant phenotype and that (2)...

Descripción completa

Detalles Bibliográficos
Autores principales: Yee, Christopher H., Zheng, Zongyu, Shuman, Lauren, Yamashita, Hironobu, Warrick, Joshua I., Wu, Xue-Ru, Raman, Jay D., DeGraff, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342925/
https://www.ncbi.nlm.nih.gov/pubmed/30670749
http://dx.doi.org/10.1038/s41598-018-36720-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342925/
https://www.ncbi.nlm.nih.gov/pubmed/30670749
http://dx.doi.org/10.1038/s41598-018-36720-6

Ejemplares similares