Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

BACKGROUND: In a genomic screen for determinants of the tumour vasculature, we identified insulin receptor (INSR) to mark the tumour endothelium. As a functional role for insulin/INSR in cancer has been suggested and markers of the tumour endothelium may be attractive therapeutic targets, we investi...

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Detalles Bibliográficos
Autores principales: Nowak-Sliwinska, Patrycja, van Beijnum, Judy R., Huijbers, Elisabeth J. M., Gasull, Paula C., Mans, Laurie, Bex, Axel, Griffioen, Arjan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342959/
https://www.ncbi.nlm.nih.gov/pubmed/30559346
http://dx.doi.org/10.1038/s41416-018-0347-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342959/
https://www.ncbi.nlm.nih.gov/pubmed/30559346
http://dx.doi.org/10.1038/s41416-018-0347-8

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