The neurotoxic secreted phospholipase A(2) from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria

The β-neurotoxic secreted phospholipases A(2) (sPLA(2)s) block neuro-muscular transmission by poisoning nerve terminals. Damage inflicted by such sPLA(2)s (β-ntx) on neuronal mitochondria is characteristic, very similar to that induced by structurally homologous endogenous group IIA sPLA(2) when its...

Descripción completa

Detalles Bibliográficos
Autores principales: Šribar, Jernej, Kovačič, Lidija, Oberčkal, Jernej, Ivanušec, Adrijan, Petan, Toni, Fox, Jay W., Križaj, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342964/
https://www.ncbi.nlm.nih.gov/pubmed/30670719
http://dx.doi.org/10.1038/s41598-018-36461-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342964/
https://www.ncbi.nlm.nih.gov/pubmed/30670719
http://dx.doi.org/10.1038/s41598-018-36461-6

Ejemplares similares