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The neurotoxic secreted phospholipase A(2) from the Vipera a. ammodytes venom targets cytochrome c oxidase in neuronal mitochondria
The β-neurotoxic secreted phospholipases A(2) (sPLA(2)s) block neuro-muscular transmission by poisoning nerve terminals. Damage inflicted by such sPLA(2)s (β-ntx) on neuronal mitochondria is characteristic, very similar to that induced by structurally homologous endogenous group IIA sPLA(2) when its...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342964/ https://www.ncbi.nlm.nih.gov/pubmed/30670719 http://dx.doi.org/10.1038/s41598-018-36461-6 |