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Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice

Glutamatergic synapses constitute a major excitatory neurotransmission system and are regulated by glutamate/glutamine (Gln) cycling between neurons and astrocytes. Gln synthetase (GS) produced by astrocytes plays an important role in maintaining the cycle. However, the significance of GS during syn...

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Detalles Bibliográficos
Autores principales: Son, Hyeonwi, Kim, Sujeong, Jung, Doo-hyuk, Baek, Ji Hyeong, Lee, Dong Hoon, Roh, Gu Seob, Kang, Sang Soo, Cho, Gyeong Jae, Choi, Wan Sung, Lee, Dong Kun, Kim, Hyun Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342969/
https://www.ncbi.nlm.nih.gov/pubmed/30670758
http://dx.doi.org/10.1038/s41598-018-36619-2