Occupational-like organophosphate exposure disrupts microglia and accelerates deficits in a rat model of Alzheimer’s disease

Occupational exposure to organophosphate pesticides, such as chlorpyrifos (CPF), increases the risk of Alzheimer’s disease (AD), though the mechanism is unclear. To investigate this, we subjected 4-month-old male and female wild-type (WT) and TgF344-AD rats, a transgenic AD model, to an occupational...

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Detalles Bibliográficos
Autores principales: Voorhees, Jaymie R., Remy, Matthew T., Erickson, Claire M., Dutca, Laura M., Brat, Daniel J., Pieper, Andrew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342990/
https://www.ncbi.nlm.nih.gov/pubmed/30701080
http://dx.doi.org/10.1038/s41514-018-0033-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342990/
https://www.ncbi.nlm.nih.gov/pubmed/30701080
http://dx.doi.org/10.1038/s41514-018-0033-3

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