Effects of point mutations in the binding pocket of the mouse major urinary protein MUP20 on ligand affinity and specificity

The mouse Major Urinary Proteins (MUPs) contain a conserved β-barrel structure with a characteristic central hydrophobic pocket that binds a variety of volatile compounds. After release of urine, these molecules are slowly emitted in the environment where they play an important role in chemical comm...

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Detalles Bibliográficos
Autores principales: Ricatti, Jimena, Acquasaliente, Laura, Ribaudo, Giovanni, De Filippis, Vincenzo, Bellini, Marino, Llovera, Ramiro Esteban, Barollo, Susi, Pezzani, Raffaele, Zagotto, Giuseppe, Persaud, Krishna C., Mucignat-Caretta, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342991/
https://www.ncbi.nlm.nih.gov/pubmed/30670733
http://dx.doi.org/10.1038/s41598-018-36391-3

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