Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders

Fifty percent of inner ear disorders are caused by genetic mutations. To develop treatments for genetic inner ear disorders, we designed gene replacement therapies using synthetic adeno-associated viral vectors to deliver the coding sequence for Transmembrane Channel-Like (Tmc) 1 or 2 into sensory h...

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Detalles Bibliográficos
Autores principales: Nist-Lund, Carl A., Pan, Bifeng, Patterson, Amy, Asai, Yukako, Chen, Tianwen, Zhou, Wu, Zhu, Hong, Romero, Sandra, Resnik, Jennifer, Polley, Daniel B., Géléoc, Gwenaelle S., Holt, Jeffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342993/
https://www.ncbi.nlm.nih.gov/pubmed/30670701
http://dx.doi.org/10.1038/s41467-018-08264-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342993/
https://www.ncbi.nlm.nih.gov/pubmed/30670701
http://dx.doi.org/10.1038/s41467-018-08264-w

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