A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations

Tumour sequencing identifies highly recurrent point mutations in cancer driver genes, but rare functional mutations are hard to distinguish from large numbers of passengers. We developed a novel computational platform applying a multi-modal approach to filter out passengers and more robustly identif...

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Detalles Bibliográficos
Autores principales: Ashford, Paul, Pang, Camilla S. M., Moya-García, Aurelio A., Adeyelu, Tolulope, Orengo, Christine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343001/
https://www.ncbi.nlm.nih.gov/pubmed/30670742
http://dx.doi.org/10.1038/s41598-018-36401-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343001/
https://www.ncbi.nlm.nih.gov/pubmed/30670742
http://dx.doi.org/10.1038/s41598-018-36401-4

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