Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling

Caspase-2 is a highly conserved cysteine protease with roles in apoptosis and tumor suppression. Our recent findings have also demonstrated that the tumor suppression function of caspase-2 is context specific. In particular, while caspase-2 deficiency augments lymphoma development in the EμMyc mouse...

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Detalles Bibliográficos
Autores principales: Dorstyn, Loretta, Hackett-Jones, Emily, Nikolic, Andrej, Norris, Murray D., Lim, Yoon, Toubia, John, Haber, Michelle, Kumar, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343006/
https://www.ncbi.nlm.nih.gov/pubmed/30670683
http://dx.doi.org/10.1038/s41419-018-1296-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343006/
https://www.ncbi.nlm.nih.gov/pubmed/30670683
http://dx.doi.org/10.1038/s41419-018-1296-0

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