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The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication
The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, includ...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343007/ https://www.ncbi.nlm.nih.gov/pubmed/30670689 http://dx.doi.org/10.1038/s41467-019-08299-7 |
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| author | Zhuang, Xiaodong Magri, Andrea Hill, Michelle Lai, Alvina G. Kumar, Abhinav Rambhatla, Srinivasa Bhargav Donald, Claire L. Lopez-Clavijo, Andrea F. Rudge, Simon Pinnick, Katherine Chang, Wai Hoong Wing, Peter A. C. Brown, Ryan Qin, Ximing Simmonds, Peter Baumert, Thomas F. Ray, David Loudon, Andrew Balfe, Peter Wakelam, Michael Butterworth, Sam Kohl, Alain Jopling, Catherine L. Zitzmann, Nicole McKeating, Jane A. |
| author_facet | Zhuang, Xiaodong Magri, Andrea Hill, Michelle Lai, Alvina G. Kumar, Abhinav Rambhatla, Srinivasa Bhargav Donald, Claire L. Lopez-Clavijo, Andrea F. Rudge, Simon Pinnick, Katherine Chang, Wai Hoong Wing, Peter A. C. Brown, Ryan Qin, Ximing Simmonds, Peter Baumert, Thomas F. Ray, David Loudon, Andrew Balfe, Peter Wakelam, Michael Butterworth, Sam Kohl, Alain Jopling, Catherine L. Zitzmann, Nicole McKeating, Jane A. |
| author_sort | Zhuang, Xiaodong |
| collection | PubMed |
| description | The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the related flaviruses dengue and Zika via perturbation of lipid signaling pathways. This study highlights a role for the circadian clock component REV-ERBα in regulating flavivirus replication. |
| format | Online Article Text |
| id | pubmed-6343007 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-63430072019-01-24 The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication Zhuang, Xiaodong Magri, Andrea Hill, Michelle Lai, Alvina G. Kumar, Abhinav Rambhatla, Srinivasa Bhargav Donald, Claire L. Lopez-Clavijo, Andrea F. Rudge, Simon Pinnick, Katherine Chang, Wai Hoong Wing, Peter A. C. Brown, Ryan Qin, Ximing Simmonds, Peter Baumert, Thomas F. Ray, David Loudon, Andrew Balfe, Peter Wakelam, Michael Butterworth, Sam Kohl, Alain Jopling, Catherine L. Zitzmann, Nicole McKeating, Jane A. Nat Commun Article The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several steps in the hepatitis C virus (HCV) life cycle, including particle entry into hepatocytes and RNA genome replication. Genetic knock out of Bmal1 and over-expression or activation of REV-ERB with synthetic agonists inhibits the replication of HCV and the related flaviruses dengue and Zika via perturbation of lipid signaling pathways. This study highlights a role for the circadian clock component REV-ERBα in regulating flavivirus replication. Nature Publishing Group UK 2019-01-22 /pmc/articles/PMC6343007/ /pubmed/30670689 http://dx.doi.org/10.1038/s41467-019-08299-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Article Zhuang, Xiaodong Magri, Andrea Hill, Michelle Lai, Alvina G. Kumar, Abhinav Rambhatla, Srinivasa Bhargav Donald, Claire L. Lopez-Clavijo, Andrea F. Rudge, Simon Pinnick, Katherine Chang, Wai Hoong Wing, Peter A. C. Brown, Ryan Qin, Ximing Simmonds, Peter Baumert, Thomas F. Ray, David Loudon, Andrew Balfe, Peter Wakelam, Michael Butterworth, Sam Kohl, Alain Jopling, Catherine L. Zitzmann, Nicole McKeating, Jane A. The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title | The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title_full | The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title_fullStr | The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title_full_unstemmed | The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title_short | The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication |
| title_sort | circadian clock components bmal1 and rev-erbα regulate flavivirus replication |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343007/ https://www.ncbi.nlm.nih.gov/pubmed/30670689 http://dx.doi.org/10.1038/s41467-019-08299-7 |
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