A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme

Alterations in the exonuclease domain of DNA polymerase ε (Polε) cause ultramutated tumors. Severe mutator effects of the most common variant, Polε-P286R, modeled in yeast suggested that its pathogenicity involves yet unknown mechanisms beyond simple proofreading deficiency. We show that, despite pr...

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Detalles Bibliográficos
Autores principales: Xing, Xuanxuan, Kane, Daniel P., Bulock, Chelsea R., Moore, Elizabeth A., Sharma, Sushma, Chabes, Andrei, Shcherbakova, Polina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343027/
https://www.ncbi.nlm.nih.gov/pubmed/30670691
http://dx.doi.org/10.1038/s41467-018-08145-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343027/
https://www.ncbi.nlm.nih.gov/pubmed/30670691
http://dx.doi.org/10.1038/s41467-018-08145-2

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