New Irreversible α‐l‐Iduronidase Inhibitors and Activity‐Based Probes

Cyclophellitol aziridines are potent irreversible inhibitors of retaining glycosidases and versatile intermediates in the synthesis of activity‐based glycosidase probes (ABPs). Direct 3‐amino‐2‐(trifluoromethyl)quinazolin‐4(3H)‐one‐mediated aziridination of l‐ido‐configured cyclohexene has enabled t...

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Detalles Bibliográficos
Autores principales: Artola, Marta, Kuo, Chi‐Lin, McMahon, Stephen A., Oehler, Verena, Hansen, Thomas, van der Lienden, Martijn, He, Xu, van den Elst, Hans, Florea, Bogdan I., Kermode, Allison R., van der Marel, Gijsbert A., Gloster, Tracey M., Codée, Jeroen D. C., Overkleeft, Herman S., Aerts, Johannes M. F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343074/
https://www.ncbi.nlm.nih.gov/pubmed/30307091
http://dx.doi.org/10.1002/chem.201804662

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343074/
https://www.ncbi.nlm.nih.gov/pubmed/30307091
http://dx.doi.org/10.1002/chem.201804662

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