Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico

BACKGROUND: The development of sequencing techniques and statistical methods provides great opportunities for identifying the impact of rare genetic variation on complex traits. However, there is a lack of knowledge on the impact of sample size, case numbers, the balance of cases vs controls for bot...

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Detalles Bibliográficos
Autores principales: Zhang, Xinyuan, Basile, Anna O., Pendergrass, Sarah A., Ritchie, Marylyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343276/
https://www.ncbi.nlm.nih.gov/pubmed/30669967
http://dx.doi.org/10.1186/s12859-018-2591-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343276/
https://www.ncbi.nlm.nih.gov/pubmed/30669967
http://dx.doi.org/10.1186/s12859-018-2591-6

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