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Real world scenarios in rare variant association analysis: the impact of imbalance and sample size on the power in silico
BACKGROUND: The development of sequencing techniques and statistical methods provides great opportunities for identifying the impact of rare genetic variation on complex traits. However, there is a lack of knowledge on the impact of sample size, case numbers, the balance of cases vs controls for bot...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343276/ https://www.ncbi.nlm.nih.gov/pubmed/30669967 http://dx.doi.org/10.1186/s12859-018-2591-6 |