Population pharmacokinetic-pharmacodynamic model of propofol in adolescents undergoing scoliosis surgery with intraoperative wake-up test: a study using Bispectral index and composite auditory evoked potentials as pharmacodynamic endpoints

BACKGROUND: In adolescents limited data are available on the pharmacokinetics (PK) and pharmacodynamics (PD) of propofol. In this study we derived a PK-PD model for propofol in adolescents undergoing idiopathic scoliosis surgery with an intraoperative wake-up test with reinduction of anesthesia usin...

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Detalles Bibliográficos
Autores principales: Blussé van Oud-Alblas, Heleen J., Brill, Margreke J. E., Peeters, Mariska Y. M., Tibboel, Dick, Danhof, Meindert, Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343297/
https://www.ncbi.nlm.nih.gov/pubmed/30669968
http://dx.doi.org/10.1186/s12871-019-0684-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343297/
https://www.ncbi.nlm.nih.gov/pubmed/30669968
http://dx.doi.org/10.1186/s12871-019-0684-z

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