Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology

Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated. Here, we show that Trim-Away can degrade proteins in zebrafish embry...

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Detalles Bibliográficos
Autores principales: Chen, Xiao, Liu, Mi, Lou, Hongyan, Lu, Yiyi, Zhou, Meng-Tao, Ou, Rongying, Xu, Yunsheng, Tang, Kai-Fu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343325/
https://www.ncbi.nlm.nih.gov/pubmed/30674345
http://dx.doi.org/10.1186/s13059-019-1624-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343325/
https://www.ncbi.nlm.nih.gov/pubmed/30674345
http://dx.doi.org/10.1186/s13059-019-1624-4

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